Zyban (bupropion) is a popular smoking cessation aid. It is by GSK is out of stock due to potential nitrosamine impurities found during testing. GSK halted distribution to ensure safety.
If you are a Zyban client, you can learn ‘Why is Zyban out of stock’ from this article. Additionally, Zyban’s benefits, side effects and alternative guidelines are mentioned below.
When GSk place a hold on Zyban distribution?
On December 1st, 2022, GlaxoSmithKline (GSK) took immediate action by placing a hold on the batch release and distribution of Zyban (bupropion hydrochloride) 150 mg prolonged-release tablets in the EU markets, including the UK and Switzerland.
This decision was prompted by GSK’s review of its manufacturing processes to investigate the potential presence of nitrosamine impurities, particularly nitroso-bupropion.
As a result, GSK initiated a thorough root cause investigation, although they could not provide a specific timeline for its completion due to the complexity of the investigation.
Why is Zyban out of stock?
Zyban (bupropion) is made by GlaxoSmithKline and is used to aid smoking cessation. It is a drug that affects neurotransmitters. Common side effects include dry mouth, insomnia, headache, and nausea, while more serious ones may include seizures, mood changes, and allergic reactions.
Considering the potential presence of nitrosamine impurities in zyban and their side effect, GSK places a hold on their supply. Moreover, In the US, the brand name Zyban has been discontinued. That’s one of the major reasons this medicine is out of stock in many markets.
However, if the FDA has approved generic versions of the medication, generic equivalents might be available in the market.
The benefits and services of Zyban
1. Smoking Cessation
Zyban is primarily used as an aid to quit smoking. It can help reduce withdrawal symptoms and cravings associated with nicotine addiction, making it easier for individuals to quit smoking.
2. Non-Nicotine Medication
Unlike nicotine replacement therapies (NRT), Zyban is a non-nicotine medication. This can benefit individuals who prefer to avoid using nicotine-based products to quit smoking.
3. Dual Action
Zyban is an atypical antidepressant that affects certain neurotransmitters in the brain. It helps with smoking cessation and has potential benefits for managing depression in some cases.
4. Short-Term Use
Zyban is typically used for a limited period to support individuals during the initial weeks of quitting smoking. It is not meant for long-term use, reducing the risk of dependence on the medication.
5. Flexible Dosage
The dosage of Zyban can be adjusted based on individual needs, ensuring a personalized approach to smoking cessation.
Side Effects of Zyban (Bupropion)
1. Common Side Effects
Some individuals may experience common side effects, such as dry mouth, difficulty sleeping, headache, dizziness, nausea, and changes in appetite or weight. These side effects are usually mild and temporary.
2. Risk of Seizures
Zyban may increase the risk of seizures, especially at higher doses or in individuals with a history of seizures or certain medical conditions. The risk is generally low but should be considered.
3. Mood Changes
Some people may experience mood changes, including anxiety, agitation, irritability, or thoughts of self-harm or suicide. Close monitoring is essential, especially during the initial weeks of treatment.
4. Allergic Reactions
In rare cases, allergic reactions to Zyban can occur, leading to symptoms such as skin rash, itching, swelling, severe dizziness, or difficulty breathing. If any of these occur, immediate medical attention is necessary.
5. Interaction with Alcohol
Consuming alcohol while taking Zyban can increase the risk of seizures and other side effects.
6. Other Side Effects
Less common side effects of Zyban may include insomnia, tremors, blurred vision, increased heart rate, and gastrointestinal issues.
Alternatives of Zyban
When considering quitting smoking, individuals often seek effective aids to support their journey towards a smoke-free life. Zyban (bupropion) has been a popular choice for smoking cessation. However, due to a supply disruption caused by potential nitrosamine impurities, the brand name Zyban has been discontinued in some regions.
To assist clients seeking alternatives, we present a list of viable options to aid smoking cessation. Each alternative offers unique benefits and may suit different individual needs.
It is essential to consult healthcare professionals to determine the most appropriate alternative and develop a personalized quitting plan. Proper coding ensures accurate national data collection. Here are some effective alternatives to Zyban:
| Alternative | Purpose and Uses | Names | Additional Information |
| Nicotine Replacement Therapy (NRT) | Provides immediate relief from withdrawal symptoms and urges to smoke. Effective stop smoking aid available as patches, lozenges, nasal spray, and mouth spray. Can be used with Zyban in the short term. | Nicotine Patches, Nicotine Lozenges, Nicotine Nasal Spray, Nicotine Mouth Spray | NRT delivers controlled doses of nicotine to help manage cravings. Patches offer continuous release, while faster-acting products can be used as needed. Suitable for gradual withdrawal. |
| Nicotine-Containing Vapes | Supports abstinence from smoking. More effective than Zyban. Can be used alone or with NRT. | Nicotine Vapes, Nicotine E-cigarettes | Vapes deliver nicotine through inhalation without harmful smoke. Clients can adjust nicotine levels, facilitating a personalized quitting plan. |
| Varenicline (Chantix/Champix) | Prescription medication to quit smoking. Reduces cravings and withdrawal symptoms. | Varenicline, Chantix, Champix | Varenicline is a non-nicotine medication that targets specific receptors in the brain to reduce nicotine cravings. Consult a healthcare professional for appropriate dosage and usage |
| Bupropion (Generic Zyban) | Same active ingredient as Zyban. Aids smoking cessation by reducing withdrawal symptoms and cravings | Bupropion. | Generic Zyban contains bupropion, similar to the branded Zyban. It is an effective alternative with the same mechanism of action. |
| Clonidine | Can help reduce nicotine withdrawal symptoms but is less commonly used than NRT or other alternatives. | Clonidine | Clonidine is an option for those who cannot use NRT or prefer non-nicotine alternatives. It may help manage certain withdrawal symptoms, but its effectiveness for smoking cessation is limited. |
Recommendations: Without consulting a doctor, don’t take any medicine or switch to another. Otherwise, it could be dangerous.
FAQs
How long will Zyban be out of stock?
As of December 2022, there is no specific indication of the exact timeframe for Zyban’s return to the market. The root cause investigation initiated by GSK to address the impurities is a complex process, and the timing is uncertain. Updates will be provided by GSK when available.
Can clients who used Zyban in the past continue using it or switch to an alternative?
Clients who used Zyban in the past may have concerns over nitrosamine impurities. While the increased cancer risk is very low, some may prefer to switch to alternative stop-smoking medications. Nicotine Replacement Therapy (NRT) and nicotine-containing vapes are viable alternatives to help them maintain abstinence.
Can clients currently using Zyban continue their treatment?
Clients currently using Zyban for smoking cessation may face a disruption in their treatment due to the stockout. They need to seek help from healthcare professionals to transition to alternative stop-smoking medications such as NRT or varenicline.
Are there any safety concerns related to the nitrosamine impurities in Zyban?
The presence of nitrosamine impurities in Zyban raises potential safety concerns as they are possible human carcinogens. However, the increased cancer risk is considered very low due to the limited duration of treatment with Zyban.
Final Verdict
From this article, you get the answer to your ask, ‘Why is zyban out of stock?’ As Zyban remains temporarily unavailable, individuals seeking smoking cessation aids can consider effective alternatives like Nicotine Replacement Therapy (NRT) and nicotine-containing vapes. NRT immediately relieves withdrawal symptoms, while vapes offer a smoke-free option.
Prescription medications like varenicline (Chantix/Champix) can also be considered. Consulting healthcare professionals for personalized guidance is vital for a successful quit-smoking journey, ensuring individuals choose the most suitable alternative to enhance their chances of quitting successfully.